CombiDART is a low-cost combinatorial approach that uses two non-vertebrate model systems to rapidly assess compounds for developmental and reproductive toxicity (DART). A library of fluorescent biomarkers has been developed in both organisms to facilitate phenotypic characterisation and molecular analysis of DART effects, thus pinpointing adverse outcome pathways (AOPs) and molecular initiating events (MIEs). The combinatorial approach increases predictive power and is intended to replace rat and rabbit use for compounds with high potential for DART, enabling their elimination early in product development. Industrial partners able to provide chemicals and expert guidance are sought to help validate CombiDART to meet their end-user needs.
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